Preston boss Phil Brown is likely to be without the services of Neil Mellor.
The striker, who has netted eight goals this term, is struggling with an ankle injury that has seen him miss the last two matches and is again unlikely to participate at Deepdale.
Fellow forward Iain Hume limped off in Saturday’s defeat to Huddersfield with a knee injury and is a major doubt for Tuesday’s clash.
Jamie Proctor could play against the Latics and against Bournemouth on Saturday, but is set to undergo a hernia operation next week that will see him occupy the sidelines for at least four to six weeks.
Brown may opt to make changes as he tries to find a winning formula after four straight defeats, with experienced midfielder Graham Alexander hoping for a promotion from the bench.
Oldham manager Paul Dickov is boosted by the return of Zander Diamond.
The defender missed the home win over Wycombe on Saturday with a back injury, but, despite recovering, may have to be content with a place on the bench after the Latics kept a clean sheet against Gary Waddock’s struggling side.
Filipe Morais suffered cramp at the weekend and was replaced by Matt Smith five minutes from time, but should be fit enough to compete at Deepdale.
Dean Furman is likely to retain his place after scoring in his first start since knee surgery, with Tom Adeyemi, who made way for the returning midfielder, likely to be named among the substitutes once again.
Striker Reuben Reid remains on the sidelines for around another five to six weeks with a thigh problem, while midfielder Josh Parker is also some way off returning to the first-team fold due to a knee injury.