Preston manager Phil Brown will be without striker Leon Clarke when his rock-bottom side host the leaders.
Clarke, who scored his first goal for North End in Tuesday’s 2-2 draw with Watford, is ineligible to face his parent club under the terms of his loan.
Striker Iain Hume has been nursing a hamstring injury but is edging closer to full fitness and may come into contention to face Neil Warnock’s men.
Midfielder Paul Coutts and forward Chris Brown are also hoping to be passed fit after injury to boost North End’s options.
Boss Brown said: “We will have Iain Hume hopefully back to add a little bit of strength to the strikeforce.
“I have fingers crossed that they [Chris Brown and Paul Coutts] are going to be throwing their hat in the ring, but these players have been out for a while and are lacking a bit of game time.”
Tommy Smith will be missing from the QPR squad.
The winger scored Rangers’ goal in last Sunday’s 1-1 draw with Nottingham Forest, but suffered a recurrence of a hamstring injury before half-time and faces another fortnight on the sidelines.
With Smith out and Hogan Ephraim halfway through a three-match ban, Norwegian international Petter Vaagen Moen could be handed a rare start in midfield.
Boss Neil Warnock could shake up his defence after blasting them for conceding against Forest so Danny Shittu could make his first appearance since returning to the club.
Midfielder Akos Buzsaky (knee) will not be risked, while Peter Ramage (cruciate), Jamie Mackie and Patrick Agyemang (both broken leg) remain long-term absentees.