Benitez is already without Glen Johnson because of a knee injury sustained in the win at Aston Villa on Tuesday, while midfielder Javier Mascherano is still serving a suspension.
Liverpool need to do well in the FA Cup considering their poor season, so Benitez will mix his side with experienced and fringe players.
Albert Riera, back in training after a calf injury, is unlikely to be involved.
Reds (from): Reina, Carragher, Agger, Skrtel, Aurelio, Insua, Darby, Dossena, Benayoun, Gerrard, Kuyt, Babel, Kyrgiakos, Spearing, Aquilani, Lucas, Ngog, Pacheco, Cavalieri.
Kick-off is 5.15pm.