Midfielder Irvine and forward Boyce are both on the mend after missing the 2-2 draw at Hamilton last weekend.
Rocco Quinn is getting closer to a return from hip surgery after playing 70 minutes in a development game, while his fellow midfielder Ben Frempah and Richard Brittain are back in full training but not ready to feature in the first team.
Darren Barr (knee) remains on the sidelines for the Staggies who were beaten 2-1 at home by Killie back in August, although they avenged that defeat with a 3-0 win at Rugby Park in November.
Kilmarnock interim boss Gary Locke has defender Darryl Westlake back in the squad as he returns from suspension.
Midfielder Euan Smith has picked up a knock and he will be assessed before the match.
Rory McKenzie (knee), defender Mark Connolly (broken collarbone), midfielder Jamie Hamill (ankle) and striker Michael Ngoo (ankle) remain on the sidelines.
Kilmarnock are just three points outside the top six and will be looking to bolster their chances of a top-half finish against relegation threatened St Mirren who sit bottom of the table.