Sheffield United midfielder Lee Williamson has been ruled out.
Williamson sustained a nasty gash just below the knee in a challenge with Leyton Orient’s Charlie Daniels only five minutes after stepping off the substitutes’ bench in the weekend draw in London.
Daniels was sent off for his indiscretion, while the Blades are waiting for the results of a scan to determine the full extent of Williamson’s injury.
Striker Chris Porter, who scored his fifth goal of the season on Saturday, could also miss out.
Porter is rated as 50/50 due to a bruised ankle sustained at Brisbane Road and if he loses his fitness battle Ched Evans will vie for a place alongside on-loan Billy Clarke with Richard Cresswell, who was omitted from the squad altogether at the weekend.
The Blades, fifth in the table, are bidding to extend their unbeaten league run to four matches.
Manager Karl Robinson will be forced to make at least one change.
Clinton Morrison played the final game of his month-long loan spell from Sheffield Wednesday as the Dons drew 0-0 at home to Scunthorpe on Saturday.
His return to Hillsborough could result in a start for Jabo Ibehre, who played 45 minutes as a second-half substitute against the Iron after recovering from the hamstring injury that had sidelined him for a month.
Robinson revealed that two defenders are nursing knocks from the weekend and are doubts ahead of the trip to Sheffield, but he did not name those players in question.
Midfielder Jay O’Shea continues to recover from an ankle problem.