Skipper Jim Bentley remains absent with a shoulder injury while Wayne Curtis (knee) and Garry Hunter (groin) are also still sidelined.
On-loan Huddersfield striker Phil Jevons is doubtful due to a bout of flu which could rule him out and Fraser McLachlan also looks certain to be missing.
The midfielder sustained a leg injury in Saturday’s 2-2 draw against Hereford and was replaced after just 12 minutes by Craig Stanley.
He could now be asked to deputise from the start as McIlroy’s men go in search of another famous victory against their Lancashire rivals.
Two years ago in the Carling Cup, Morecambe beat North End 2-1 at the same stage of the competition.