Raheem Sterling will deputise for Dele Alli in the No 10 position for England against Slovenia on Thursday.
England head into their clash with Slovenia at Wembley hoping to secure qualification to the 2018 World Cup.
The Three Lions realistically need only one point from their remaining two games to assure themselves of a place at the finals in Russia.
With Alli suspended, Gareth Southgate could be tempted to change formation instead of using a like-for-like replacement, but he is reluctant to alter a system that has seen England go undefeated in qualifying.
As a result, Manchester City winger Sterling will move central behind striker Harry Kane against Slovenia.
Alex Oxlade-Chamberlain will also be trusted on the right-hand side of a three-man attack, with Marcus Rashford on the left.
It will be the first time Sterling, Rashford and Kane have all played together on the international stage.
Likely England XI against Slovenia (4-2-3-1): Hart; Walker, Stones, Cahill, Bertrand; Dier, Henderson; Oxlade-Chamberlain, Sterling, Rashford; Kane.