Latics will be without captain Gary Caldwell for the rearranged meeting with Villa.
Caldwell faces a one-match ban following his dismissal in the 3-0 defeat at Arsenal on Saturday, the ninth red card of his career.
With fellow centre-back Antolin Alcarez also now ruled out for two weeks with a soft tissue injury, it means Steven Caldwell and Steve Gohouri form the pairing at the heart of the defence.
Midfielder James McCarthy is poised to figure after a three-month lay-off with an ankle injury, although is unlikely to start, while goalkeeper Chris Kirkland is also available after recovering from a head injury.
New signing Jean Makoun is set to make his Villa debut against Wigan.
The central midfielder, signed from Lyon, is in the squad and may even start the match. Villa also welcome back Emile Heskey from suspension, and Kyle Walker from a back injury.
Stephen Warnock, who has been linked with Liverpool, is still training with the reserves and will not feature in the match. Stephen Ireland remains sidelined with a knee complaint.
Wigan (from): Al Habsi, Pollitt, Kirkland, Gohouri, Stam, Figueroa, Watson, Diame, McArthur, McCarthy, Thomas, N’Zogbia, McManaman, Rodallega, Lopez, Gomez, S Caldwell, Robinson, Boyce, De Ridder, Golobart, Mustoe, Di Santo.
Villa (from): Friedel, L Young, Makoun, Dunne, Downing, A Young, Pires, Agbonlahor, Albrighton, Delfouneso, Heskey, Petrov, Reo-Coker, Clark, Cuellar, Bannan, Collins, Marshall, Bent, Lichaj, Baker, Herd, Hogg, Walker.